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Research at Adventist HealthCare

Current clinical trials

Currently Recruiting Clinical Trials

Breast Cancer

REDISCOVER 
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/​HER2- Breast Cancer (ReDiscover-2)
https://clinicaltrials.gov/study/NCT06982521 

Germ Cell Cancer

P3BEP 
Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for participants with intermediate and poor risk metastatic germ cell tumours
https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12613000496718 

OVARIAN CANCER

MEN2501-01
A Phase 1, First-In-Human Study Of Men2501, A Kif18a Inhibitor, As Monotherapy In Participants With Platinum-Resistant Ovarian Cancer

Prostate Cancer

ORIC-944-01
An Open-Label, Phase 1/1b Study of ORIC-944 as a Single Agent or in Combination with an Androgen Receptor Pathway Inhibitor in Patients with Metastatic Prostate Cancer
https://clinicaltrials.gov/study/NCT05413421 

WOMBAT

Working Out M0 Bipolar Androgen Therapy (WOMBAT)
https://clinicaltrials.gov/study/NCT06594926 

Solid Tumours

CONTEXT
A Phase 1a/1b, First-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants with Recurring Triple Negative Breast, Colorectal, Urothelial Cancers
https://clinicaltrials.gov/study/NCT07545122

Cancer - Peripheral Neuropathy

INFOCUS
Peripheral Neuropathy in Chemotherapy-treated Patients: Predictors, Assessment strategies and Functional Outcomes: IN FOCUS (Identifying Neurological and Functional Outcomes in Cancer Survivors Study)

Kidney Disease / Renal

PYC-003-CL-001
A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Intravenously Administered PYC-003, a Peptide-phosphorodiamidate Morpholino Oligonucleotide Conjugate, in Healthy Adult Participants and Adult Participants With Confirmed PKD1 Mutation-associated Autosomal Dominant Polycystic Kidney Disease
https://clinicaltrials.gov/study/NCT06714006 

POSIBIL6ESKD

A Phase 2b / 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Combined Dose-Finding and Cardiovascular Outcome Study to Investigate the Efficacy and Safety of CSL300 (Clazakizumab) in Subjects With End Stage Kidney Disease Undergoing Dialysis
https://clinicaltrials.gov/study/NCT05485961 

RESOLVE
Randomised Evaluation of Sodium Dialysate Levels on Vascular Events

Menopause

ADELE
A real-world observational study describing sleep outcomes among women with vasomotor symptoms associated with menopause using fezolinetant in Australia

CROHNS DISEASE

SIBERITE-2
A Phase III, Multicenter, Double-Blind, Placebo-Controlled Study To Assess The Efficacy And Safety Of Induction Therapy With Ro7790121 In Patients With Moderately To Severely Active Crohn's Disease
https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=23916&isClinicalTrial=True

For more information please contact us at SanTrials@sah.org.au.